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Miguel Coelho, PhD
Publications
- Heterozygous mutations cause genetic instability in a yeast model of cancer evolution (Nature, 2019):
"One rogue agent suffices for genomic chaos" (Nature News & Views, 2019)
- Horizontal Gene Acquisitions, Mobile Element Proliferation, and Genome Decay in the Host-Restricted Plant Pathogen Erwinia Tracheiphila (Genome Biol Evol, 2016 - Collaboration with Lori Shapiro)
- Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles (Bioessays, 2015)
-Fusion leads to effective segregation of damage during cell division: An analytical treatment (J Theor Biol, 2015 - Collaboration with Steve Lade)
-Aging and stress – the role of the environment in cellular replication
(The Biochemist, 2015)
- Fusion of Protein Aggregates Facilitates Asymmetric Damage Segregation
(PLoS Biol. 2014):
"Stressed yeast paint a picture of Dorian Gray" (PLoS Biol. Dispatch)
- Fission yeast does not age under favorable conditions, but does so after stress (Curr.Biol. 2013):
"This paper reports the surprising finding that fission yeast cells show no replicative ageing..."(Faculty of 1000),
"Cellular Aging: Symmetry Evades Senescence" CB dispatch by J.Moseley,
"Sequestration stress" Science Editor's choice
- Single-molecule imaging in vivo: the dancing building blocks of the cell (Integr. Biol. 2013 - most downloaded article of Integrative Biol. 2013)
- Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). (J. Gerontol. A. Biol. Sci. Med. Sci. 2013)
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(2012, Dissertation, Technische Universtitat Dresden - TUD).
- Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. (J. Gerontol. A. Biol. Sci. Med. Sci. 2011)
- Refreshed but vulnerable: yeast daughter cells are more sensitive to stress than young mothers. (Cell cycle, 2011)
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