Miguel Coelho, PhD

Name:            Miguel Costa Coelho

Address:        Northwest B.,52 Oxford st, Cambridge, MA, 02138

Tel.:                 (+1)6174183422

E-mail:            mcc150@gmail.com

 

Academic record

Jun-Jul 2014 Mini-MBA, Harvard Business School, Cambridge, USA

 

Sep 2013            Post-doctoral work in Harvard University (FAS center for Systems Biology), USA

 

Feb 2012/ Jun 2013   MPI-CBG, Dresden, Germany: Postdoc in Tolic-Norrelykke group

 

Jul-Aug 2010  Molecular Biology of Ageing course, MBL, Woods Hole, US

Project: Ageing and stress resistance in different clam species

 

Sep 2007/ Jan 2012  International Max-Planck Research School (IMPRS) at MPI-CBG and TUDresden, Germany (PhD in Biology: Magna cum laude)

Thesis: Ageing by passive aggregation and stochastic distribution of protein aggregates

 

Sep 2005/ Aug 2007  IGC (Gulbenkian), Oeiras, Portugal: Research associate in Soares group

Projects:        Ciliary biogenesis in Tetrahymena, Response to mechanical stress

 

Sep 2007 FCUL, Lisbon, Portugal  (MSc in Biochemistry: 16/20)

Thesis: Molecular studies of ciliary biogenesis in Tetrahymena (19/20)

 

Work experience

 

Jun-Aug 2014 Teaching at Undergraduate Summer Internships (FAS Center for SysBio, Harvard).

 

Sep 2011/ Jun 2013  MPI-CBG, Dresden, Germany: Predoc/Postdoc in Tolic-Norrelykke group

Projects:        Protein aggregation and damage segregation at cell division

Studies of replicative ageing in the fission yeast Schizosaccharomyces pombe

Telomere dynamics in meiosis

 

Aug 2011           Summer School of Science (S3++), Visnjan, Croatia: Project Leader

Project:           The role of molecular chaperones in cellular ageing

 

Sep 2004/Aug 2007  IGC (Gulbenkian), Oeiras, Portugal: Research associate in Soares group

Projects:        Ciliary biogenesis in Tetrahymena, Response to mechanical stress

 

Awards and Grants

April 2014: Human Frontier Science Program Long-Term Fellowship (LTD)

Jan 2014: DFG Postdoctoral Fellowship (declined)

Jun 2010: Elison Medical Foundation stipend for the Aging course, MBL, Woods Hole, US

Nov 2008: Prof. Kai Simons award for “Creative writing in Science”

Oct 2007: Research grant and PhD fellowship (SFRH/BD/37056/2007) from FCT, Portugal

Oct 2006: IEFP professionalizing internship stipend, IGC, Oeiras, Portugal

 

Conferences: Oral Presentations

2014: EMBO Experimental approaches to Evolution and Ecology using Yeast, Germany 

2012:   EMBO Germline: Immortality through totipotency, Germany (Travel award) 

DGZ Meeting, Germany

2011:   EMBO Molecular biology of chaperones, Austria

2010:   Mechanobiology of Mitosis, Croatia;

Circle Meeting, AMOLF, Netherlands

PhD seminar, MPI-CBG, Germany

2008:   MPI-PKS Dresden, Germany

Instituto Gulbenkian de Ciencia (IGC), Portugal (Invited speaker)

Asia-Pacific S.pombe meeting, TLL, Singapore (Travel award)

 

Conferences: Poster presentations

2012:   EMBO meeting, Nice, France (Poster award, Travel award, EMBO journal)

2010:   Mechanobiology of Mitosis, Hvar, Croatia

EMBO microtubule conference, Heidelberg, Germany

2009:   5th International Fission yeast Meeting, Tokyo, Japan

2008:   MSB2008, Microfluidic conference, Berlin, Germany (Travel award)

2007:   ELSO 2007, Dresden, Germany

4th International Fission yeast Meeting, Copenhagen, Denmark

2005:   FASEB “Ciliate molecular biology”, Il Ciocco, Italy

 

Publications

1. Articles:

- Coelho,M; et al "Heterozygous mutations cause genetic instability in a yeast model of cancer evolution", Nature, 2019

- Coelho,M.; Lade, S. "Fusion of protein aggregates facilitates asymmetric damage segregation", PloS Biol. 2014

- Coelho, M. et al; “Fission yeast does not age under favorable conditions, but does so after stress”, Curr. Biol.,2013

- Coelho, M. et al; “Single-molecule imaging in vivo: The dancing building blocks of the cell”, Integrative Biology, 2013

- Ungvari, Z. et al; “Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa)”, Journal of Gerontology, 2012

- Ungvari, Z.et al;"Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal", Journal of Gerontology, 2011

2. Other publications:

- Coelho, M., Tolic-Norrelykke, I.M.;"Refreshed but vulnerable: yeast daughter cells are more sensitive to stress than young mothers", (News and Views) Cell Cycle, 2011

 

Acquired skills and expertise: experimental evolution, whole genome analysis, live cell imaging, single molecule microscopy, image analysis, quantitative biology, molecular genetics, biochemistry, microfluidics, bioinformatics, scientific writing, experimental design, graphic design, teaching, presentation, communication.

 

Languages: Portuguese, English (fluent); German, French, Spanish, Italian (basic).